This might be a little annoying because by default mutt saves attachments in the directory that it was started from (most likely ~/), and there is no config option that I'm aware of to set a default download location.
A user will either need to manually specify a location (like ~/Downloads) when saving, or allow saving to ~/ in the local override.
AppArmor profile for mutt.
There are an innumerable number of mutt configurations. This AA profile is intended to work with a stock mutt config. Any customizations should be placed in local/mutt